After seasonal harvests of specific cultivars, these high-CBD hemp crops are put through a specialized solvent-free extraction process to yield a hemp oil that is naturally high in cannabidiol. This pure hemp extract is then tested for safety, quality, and cannabinoid content before being exported to our processing facilities in the United States. Importing any cannabis or hemp product into the United States is a complicated and serious task, so we leave nothing to chance before our high-CBD hemp oil makes its journey across the Atlantic Ocean.
In fact, the U.S. Food and Drug Administration (FDA) approved Epidiolex (a drug made with a purified form of CBD oil) in June 2018 for the treatment of seizures associated with two rare and severe forms of epilepsy in patients 2 years of age and older. These two epilepsy forms are known as Lennox-Gastaut syndrome and Dravet syndrome. Epidiolex is the first FDA-approved drug that contains a purified drug substance derived from marijuana.
Given CBD’s reputation as a popular, artisanal remedy, one would think that Epidiolex would command a lot of “off label” attention. After all, physicians often prescribe pharmaceuticals off label to treat conditions that were not the actual focus of clinical trials. But the costly price tag for Epidiolex (more than $30,000 annually) precludes off label prescribing as well as affordable access for tens of millions of Americans without health insurance.
This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor’s advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Individual weight loss results will vary. By using this site you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited By Law.
Mike, what kind of breast cancer (invasive ductal, I presume)? How many of her lymph nodes were positive? How big was the primary tumor? Reason I ask is that in women with Stage I or IIA tumors that are estrogen-and progesterone-receptor-positive and HER2-negative (ER+/PR+/HER2-) with three or fewer positive lymph nodes, there is a genomic assay test on a sample of the tumor, called OncotypeDX, that will tell doctors whether chemo is necessary or would even work at all. Medicare covers that test 100%.That type of breast cancer mentioned above, which I had as Stage IA, is treated in postmenopausal women with anti-estrogen drugs called aromatase inhibitors(aka AIs: anastrazole, letrozole, or exemestane)which have as a side effect joint pain. CBD oil is effective for this joint pain it is not, I repeat, NOT a substitute for chemo, radiation or these anti-estrogen drugs.So don’t assume your mom’s cancer will require chemo; but if it does, CBD helps with those side effects as well. If she lives in a state where medical marijuana is legal, there are doctors who sub-specialize in certifying applications for a medical marijuana card, and in the interim before the card is issued can advise as to the appropriate dose of CBD oil (legal and over-the-counter in all 50 states). Some (though not most) medical oncologists will certify their own patients’ medical marijuana card applications so she need not seek out another doctor; and will advise the appropriate dose for her symptoms. Once she gets her card, the “budtenders” in the licensed dispensaries can advise her as to the right CBD product (with or without THC), strength, and dosage. If she lives in a state where recreational weed is legal, the “budtenders” in the marijuana shops can steer her to the right strength of CBD oil and the right dosage.

Cannabidiol has been found to act as an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain.[30] It has also been found to act as an inverse agonist of GPR3, GPR6, and GPR12.[12] Although currently classified as orphan receptors, these receptors are most closely related phylogenetically to the cannabinoid receptors.[12] In addition to orphan receptors, CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist,[31] and this action may be involved in its antidepressant,[32][33] anxiolytic,[33][34] and neuroprotective effects.[35][36] It is an allosteric modulator of the μ- and δ-opioid receptors as well.[37] The pharmacological effects of CBD have additionally been attributed to PPARγ agonism and intracellular calcium release.[7]

I have been using the 1000mg tincture and find that it is very effective at taming anxiety once I found the dosage that worked for me. I started small at 1 drop 3x per day because I had never used CBD before and found that 4 drops 3x a day is currently appropriate to get the results I am looking for. I am glad I found Medterra. Before making a CBS purchase, I did tons of research and felt that they were one of the best in the market. Customer Service response time was same day when I sent them a question.

My mom has terminal metastatic breast cancer and her bone metastases are incredibly painful. Not only does this product keep her pain tolerable but it has also decreased her depression and anxiety significantly. She no longer has those ups and downs but finally feels GOOD. Thank you for giving my mom her quality of life back so we can truly enjoy our time with her. For reference she takes 1000 mg 2xday.
In September 2018, following its approval by the FDA for rare types of childhood epilepsy,[13] Epidiolex was rescheduled (by the Drug Enforcement Administration) as a Schedule V drug to allow for its prescription use.[14] This change applies only to FDA-approved products containing no more than 0.1 percent THC.[14] This allows GW Pharmaceuticals to sell Epidiolex, but it does not apply broadly and all other CBD-containing products remain Schedule I drugs.[14] Epidiolex still requires rescheduling in some states before it can be prescribed in those states.[65][66]

Nabiximols (brand name Sativex) is a patented medicine containing CBD and THC in equal proportions. The drug was approved by Health Canada in 2005 for prescription to treat central neuropathic pain in multiple sclerosis, and in 2007 for cancer related pain.[39][40] In New Zealand Sativex® is approved for use as an add-on treatment for symptom improvement in patients with moderate to severe spasticity due to Multiple Sclerosis who have not responded adequately to other anti-spasticity medication and who demonstrate clinically significant improvement in spasticity related symptoms during an initial trial of therapy.[41]
This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor’s advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Individual weight loss results will vary. By using this site you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited By Law.
Stephanie, generally, I have patients take 20 to 150mg a day for sleep +/- anxiety. Start low and go slow. Know the dosages of your product. Usually 2/3 to 3/4 of the daily dose is 1-2 hours before bedtime, and the other portion is upon waking (to improve wakefulness during the day). Other factors such as stress, hormone replacement, other meds & medical conditions, etc. play a role along with individual differences. I own a compounding pharmacy, so we see a lot of unique needs. I can't give more specific advice in this forum, but there is help!
I purchased the 500 mg tincture to start. I make CBD but I use a different process that does not extract like the CO2 method The CO2 method is the best and you have to be careful when choosing CBD. Make sure that its organic NO GMO and grown in the USA I love how clear it is although it does have a little bit of cloudiness but this is normal. I have been using CBD to relieve anxiety I am agoraphobic and part of that is severe panic attacks. With my first 1 ML dose as soon as it came in the mail today I was starting to relax. I am only guessing but I will probably be taking 1 ML twice per day since this is the 500mg bottle once when I get up and once before bed so this bottle will not last me a month. If it works as well as expected especially after the first dose this morning then I will probably move up to the 1000 mg which will last me the month. One other thing you may have already read this information but this CBD has 0 THC. Thats important for those who work in professions that can not risk having high THC levels no pun intended.What makes me so confident in this product is how fast it worked. 1 ML under the tongue is the best way in my opinion to get the CBD oil to act quickly. This product gets great reviews for pain as well. Fortunately I dont suffer pain just anxiety and panic attacks. Thank you Medterra PS. I was not paid for this review LOL. I paid full price for this product and happy to do it.If Im able I will update this review if needed when I finish this bottle. Or leave another when I get the 1000 mg.
CBD oils may contain some THC. Cannabis may impair your ability to drive safely or operate equipment and may have short- and long-term effects on your memory, attention, mood, heart rate, and mental health. It is also easy to overconsume CBD oil, so it's important to start with a low dose, as it may take several hours or longer to begin to feel the effects after consumption.
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